Ultracet has been approved by the FDA for the short-term five days or less management of acute pain. This medication is a centrally acting analgesic that controls pain through different mechanisms of action than non-steroidal anti-inflammatory drugs NSAIDs , the most commonly used pain medications.
As a result, Ultracet is not associated with the side effects that can result from NSAID use, such as gastrointestinal ulcers or bleeding. Ultracet combines Ultram tramadol HCl , a leading prescription pain reliever, with the common non-prescription pain treatment, acetaminophen. Clinical trials have shown that the combination is more effective than either drug alone, providing longer duration than acetaminophen and a faster onset of action than tramadol. Tramadol is a centrally acting synthetic opioid analgesic.
Although its mode of action is not completely understood, from animal tests, at least two complementary mechanisms appear applicable: binding of parent and M1 metabolite to mu-opioid receptors and weak inhibition of reuptake of norepinephrine and serotonin. Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to mu-opioid receptors. In animal models, M1 is up to six times more potent than tramadol in producing analgesia and times more potent in mu-opioid binding.
Tramadol-induced analgesia is only partially antagonized by the opiate antagonist naloxone in several animal tests. The relative contribution of both tramadol and M1 to human analgesia is dependent upon the plasma concentrations of each compound. With proper use, paracetamol seldom causes adverse events and reports of serious side effects are rare.
It has a broad tolerability and is of particular value in the treatment of patients in whom nonsteroidal anti-inflammatory drugs are contraindicated such as aspirin-sensitive asthmatics and people at risk of gastrointestinal complications. In the future, a better insight into the mechanism of action of paracetamol may be gained from a fuller understanding of the cyclooxygenase enzymes.
In the meantime, paracetamol may find applications in other therapeutic areas, such as the prevention of atherosclerosis via a potential antioxidant activity. In summary, although it is more than a century since the first clinical use of paracetamol, it continues to be a first-line therapy of choice in adults and children with fever and pain. Chemistry at Home Explore chemistry education resources by topic that support distance learning. Find a chemistry community of interest and connect on a local and global level.
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